Although affected patients share the cutaneous feature of ichthyosis, there is variability in the nature and severity of neurologic disease. Impaired cognition, spasticity, sensorineural deafness, visual impairment, and/or seizures are the primary neurologic findings.

What characteristics are common of neurological disorders?

Physical symptoms of neurological problems may include the following:

  • Partial or complete paralysis.
  • Muscle weakness.
  • Partial or complete loss of sensation.
  • Seizures.
  • Difficulty reading and writing.
  • Poor cognitive abilities.
  • Unexplained pain.
  • Decreased alertness.

What is neurological syndrome?

Neurological disorders are medically defined as disorders that affect the brain as well as the nerves found throughout the human body and the spinal cord. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms.

Can neurological disorders develop?

Many neurologic disorders emerge during the early years of development and may be diagnosed at birth. Some are diagnosed later because symptoms only appear when: A child misses developmental milestones or has developmental difficulties (e.g. autism). A damaging infection occurs (e.g. meningitis).

What is the life expectancy of someone with ichthyosis?

People with mild ichthyosis have a normal lifespan. However, the most severe inherited types can be life threatening. If you have inherited ichthyosis, you’ll have it for life. Acquired ichthyosis may get better if the underlying cause is identified and treated.

Can neurological symptoms come and go?

Signs and symptoms vary, depending on the type of functional neurologic disorder, and may include specific patterns. Typically these disorders affect your movement or your senses, such as the ability to walk, swallow, see or hear. Symptoms can vary in severity and may come and go or be persistent.

Is ichthyosis an autoimmune disease?

The association of autoimmune conditions with acquired ichthyosis could indicate that an abnormal host immune response, probably against components of the granular cell layer in particular the keratohyalin granules, may have a role in the pathogenesis.