Trichothiodystrophy, which is commonly called TTD, is a rare inherited condition that affects many parts of the body. The hallmark of this condition is brittle hair that is sparse and easily broken. Tests show that the hair is lacking sulfur, an element that normally gives hair its strength.
What is Ibids syndrome?
IBIDS syndrome, following the acronym from ichthyosis, brittle hair and nails, intellectual impairment and short stature, is the Tay syndrome or sulfur-deficient brittle hair syndrome, first described by Tay in 1971.
What are the signs and symptoms of trichothiodystrophy?
The signs and symptoms of trichothiodystrophy vary widely. Mild cases may involve only the hair. More severe cases also cause delayed development, significant intellectual disability, and recurrent infections; severely affected individuals may survive only into infancy or early childhood.
What are the complications of trichothiodystrophy during pregnancy?
Mothers of children with trichothiodystrophy may experience problems during pregnancy including pregnancy-induced high blood pressure (preeclampsia) and a related condition called HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome that can damage the liver.
What are the symptoms of early stage ovarian cancer in women?
Women are more likely to have symptoms if the disease has spread, but even early-stage ovarian cancer can cause them. The most common symptoms include: Bloating. Pelvic or abdominal (belly) pain. Trouble eating or feeling full quickly.
What are the diagnostic findings of trichoschisis and trichorrhexis?
The diagnostic findings of TTD are short, unruly, brittle hair, with alternating dark and light bands under polarizing microscopy (tiger-tail pattern), trichoschisis (or trichorrhexis), and an absent or defective cuticle visualized by scanning electron microscopy. TTD is a differential diagnosis in congenital alopecias.
