These cis-regulatory sequences include enhancers, silencers, insulators and tethering elements. Among this constellation of sequences, enhancers and their associated transcription factor proteins have a leading role in the regulation of gene expression.
What is eukaryotic transcriptional control?
Transcription control factors promote or prevent RNA polymerase binding. Various trans‐acting factors (proteins) bind at specific cis‐acting sequences. These factors can bind upstream of the promoter.
Does a eukaryotic gene have control elements?
Unlike prokaryotic cells, eukaryotic cells can regulate gene expression at many different levels. Eukaryotic gene expression begins with control of access to the DNA. This form of regulation, called epigenetic regulation, occurs even before transcription is initiated.
What are some of the steps in eukaryotic transcriptional control?
Stages of eukaryotic gene expression (any of which can be potentially regulated).
- Chromatin structure. Chromatin may be tightly compacted or loose and open.
- Transcription.
- Processing and export.
- mRNA stability.
- Translation.
- Protein processing.
Where does transcriptional control occur?
In Summary: Post-TransCRIPTIONAL Control of Gene Expression Post-transcriptional control can occur at any stage after transcription, including RNA splicing, nuclear shuttling, and RNA stability. Once RNA is transcribed, it must be processed to create a mature RNA that is ready to be translated.
What is involved in post transcriptional control?
Posttranscriptional regulation includes alternative splicing (which determines the translated mRNA sequence itself), stability of the mRNA strand (which can be actively degraded in a regulated manner), transport of the mRNA to the ribosome, and binding of mRNA to the ribosome.
What is involved in post-transcriptional control?
Which of the following is an example of post-transcriptional control of gene expression?
The removal of introns and alternative splicing of exons is an example of post-transcriptional control of gene expression.
What factors are involved in transcriptional control?
Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes.
Where do transcriptional regulators most commonly bind to?
Some transcription factors bind to a DNA promoter sequence near the transcription start site and help form the transcription initiation complex. Other transcription factors bind to regulatory sequences, such as enhancer sequences, and can either stimulate or repress transcription of the related gene.
Does post-transcriptional splicing happen in eukaryotes?
RNA Splicing, the First Stage of Post-transcriptional Control. In eukaryotic cells, the RNA transcript often contains regions, called introns, that are removed prior to translation. The regions of RNA that code for protein are called exons (Figure 16.11).
