Aspirin can be made by reacting salicylic acid with acetic acid in the presence of an acid catalyst. The phenol group on the salicylic acid forms an ester with the carboxyl group on the acetic acid. However, this reaction is slow and has a relatively low yield.
How do you calculate the theoretical yield of aspirin?
question 1
- Moles of Salicylic Acid = Moles of Aspirin —> 2 moles of Salicylic Acid makes 2 moles of Asprin.
- Molar Mass of Aspirin = 180.16 g.
- Theoretical yield of Aspirin (g) = (2 moles)(molar mass of aspirin) = 2.000(180.16) = 360.3 grams.
What is the electrophile in aspirin synthesis?
An addition elimination reaction occurs at the carbonyl carbon where a nucleophile attacks the highly electrophilic carbonyl carbon. Once Salicylic Acid (limiting reagent) is synthesized, it too can undergo a carbonyl addition-elimination with acetic anhydride to produce aspirin.
Where is aspirin manufactured?
China
Most of the North American supply of aspirin, for example, comes from China, which produces about 120 billion tablets per year. Other widely used drugs, such as omeprazole and simvastatin often come from Puerto Rico and India.
Where is aspirin manufactured by which companies?
Manufacturer: Reckitt Benckiser (India) Ltd.
What is produced as a byproduct of the aspirin synthesis?
The byproduct of the synthesis of aspirin is acetic acid.
How do I calculate theoretical yield?
Multiply the ratio by the limiting reactant’s quantity in moles. The answer is the theoretical yield, in moles, of the desired product.
How can the percent yield in synthesis of aspirin be increased?
In a reflux reaction with aspirin, the best yield should be obtained by heating the mixture of reactants around above the solvents boiling point. This will allow for optimal heat and higher rate of collisions during reaction, allowing more product to be produced.
What is the theory behind the synthesis of aspirin?
Theory. Synthesis of Aspirin is known as esterification. Acetic anhydride is uses as it is cheap and forms a by-product, acetic acid which is not corrosive and can be recovered to make more acetic anhydride unlike other acetylating agents that also can be used.
What is the chemical name of aspirin made from?
Synthesis of Aspirin Aspirin is the single most manufactured drug in the world. Aspirin’s chemical name is acetylsalicylic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phos-phoric acid as a catalyst. The by-product is acetic acid (Figure 5.1).
What is trichlorophenol used for?
It has been used primarily in pesticide formulations and as a wood preservative, although most uses have been cancelled in the US. When heated to decomposition, 2,4,6-trichlorophenol emits toxic and corrosive fumes of hydrochloric acid and other toxic gases.
What is the molecular formula of 2-4-6-trichlorophenol?
2,4,6-Trichlorophenol PubChem CID 6914 Structure Find Similar Structures Chemical Safety Laboratory Chemical Safety Summary (LCSS Molecular Formula C6H3Cl3O or C6H2Cl3OH Synonyms 2,4,6-TRICHLOROPHENOL 88-06-2 Phenol, ..
